Following solid organ transplantation, a substantial proportion of chronic allograft loss is
attributed to the formation of donor-specific antibodies (DSAs) and antibody-mediated
rejection (AbMR). The frequency and phenotype of T follicular helper (Tfh) and T follicular
regulatory (Tfr) cells is altered in the setting of kidney transplantation, particularly in patients
who develop AbMR. However, the roles of Tfh and Tfr cells in AbMR after solid organ
transplantation is unclear. We developed mouse models to inducibly and potently perturb …