Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease
A Tan-Garcia, LE Wai, D Zheng, E Ceccarello, J Jo… - Journal of …, 2017 - Elsevier
Background & Aims Liver inflammation is key in the progression of chronic viral hepatitis to
cirrhosis and hepatocellular carcinoma. The magnitude of viral replication and the specific
anti-viral immune responses should govern the degree of inflammation, but a direct
correlation is not consistently found in chronic viral hepatitis patients. We aim to better define
the mechanisms that contribute to chronic liver inflammation. Methods Intrahepatic CD14+
myeloid cells from healthy donors (n= 19) and patients with viral-related liver cirrhosis (HBV …
cirrhosis and hepatocellular carcinoma. The magnitude of viral replication and the specific
anti-viral immune responses should govern the degree of inflammation, but a direct
correlation is not consistently found in chronic viral hepatitis patients. We aim to better define
the mechanisms that contribute to chronic liver inflammation. Methods Intrahepatic CD14+
myeloid cells from healthy donors (n= 19) and patients with viral-related liver cirrhosis (HBV …
