[HTML][HTML] SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase
KD Mir, MA Gasper, V Sundaravaradan… - Microbes and infection, 2011 - Elsevier
SIV-infected natural hosts do not progress to clinical AIDS yet display high viral replication
and an acute immunologic response similar to pathogenic SIV/HIV infections. During chronic
SIV infection, natural hosts suppress their immune activation, whereas pathogenic hosts
display a highly activated immune state. Here, we review natural host SIV infections with an
emphasis on specific immune cells and their contribution to the transition from the acute-to-
chronic phases of infection.
and an acute immunologic response similar to pathogenic SIV/HIV infections. During chronic
SIV infection, natural hosts suppress their immune activation, whereas pathogenic hosts
display a highly activated immune state. Here, we review natural host SIV infections with an
emphasis on specific immune cells and their contribution to the transition from the acute-to-
chronic phases of infection.
