Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
KMP Das, L Wechselberger, M Liziczai… - Journal of lipid …, 2018 - ASBMB
Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically
involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-
associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect
intracellular TAG levels, yet, the underlying molecular mechanisms are unclear. Here, we
show that HILPDA inhibits adipose triglyceride lipase (ATGL), the enzyme catalyzing the first
step of intracellular TAG hydrolysis. HILPDA shares structural similarity with G0/G1 switch …
involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-
associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect
intracellular TAG levels, yet, the underlying molecular mechanisms are unclear. Here, we
show that HILPDA inhibits adipose triglyceride lipase (ATGL), the enzyme catalyzing the first
step of intracellular TAG hydrolysis. HILPDA shares structural similarity with G0/G1 switch …
