Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells
PE Forni, C Taylor-Burds, VS Melvin… - Journal of …, 2011 - Soc Neuroscience
Journal of Neuroscience, 2011•Soc Neuroscience
The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic
Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the
developing nasal placode was performed using two complementary mouse models, the NC-
specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines
we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of
GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann …
Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the
developing nasal placode was performed using two complementary mouse models, the NC-
specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines
we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of
GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann …
The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal contribution to the developing nasal placode was performed using two complementary mouse models, the NC-specific Wnt1Cre mouse line and an ectodermal-specific Crect mouse line. Using these lines we prove that the NC give rise to the olfactory ensheathing cells and subpopulations of GnRH-1 neurons, olfactory and vomeronasal cells. These data demonstrate that Schwann cells and olfactory ensheathing cells share a common developmental origin. Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies.
Soc Neuroscience
