Sympathetic nerve activity is inappropriately increased in chronic renal disease
IHHT Klein, G Ligtenberg, J Neumann… - Journal of the …, 2003 - journals.lww.com
The hypothesis that in hypertensive patients with renal parenchymal disease sympathetic
activity is “inappropriately” elevated and that this overactivity is a feature of renal disease
and not of a reduced number of nephrons per se is addressed. Fifty seven patients with
renal disease (various causes, no diabetes, all on antihypertensive medication) were
studied, age range 18 to 62, creatinine clearance 10 to 114 ml/min per 1.73 m 2.
Antihypertensives were stopped, but diuretics were allowed, to prevent overhydration …
activity is “inappropriately” elevated and that this overactivity is a feature of renal disease
and not of a reduced number of nephrons per se is addressed. Fifty seven patients with
renal disease (various causes, no diabetes, all on antihypertensive medication) were
studied, age range 18 to 62, creatinine clearance 10 to 114 ml/min per 1.73 m 2.
Antihypertensives were stopped, but diuretics were allowed, to prevent overhydration …
