High-dose oral vitamin D3 supplementation in rheumatology patients with severe vitamin D3 deficiency
C von Restorff, HA Bischoff-Ferrari, R Theiler - Bone, 2009 - Elsevier
C von Restorff, HA Bischoff-Ferrari, R Theiler
Bone, 2009•ElsevierOBJECTIVES: Recent large trials indicate that adherence associated with a daily regimen of
vitamin D is low and limits anti-fracture efficacy with vitamin D supplementation. The aim of
this report is to describe changes of 25-hydroxyvitamin D (25 (OH) D) serum concentrations
achieved with a single oral dose of 300000 IU vitamin D3. METHODS: Over a course of 4
months, we identified 33 elderly with severe vitamin D deficiency (25 (OH) D< 25 nmol/l) on
admission to acute care. Patients were admitted for musculoskeletal pain, bone disease, or …
vitamin D is low and limits anti-fracture efficacy with vitamin D supplementation. The aim of
this report is to describe changes of 25-hydroxyvitamin D (25 (OH) D) serum concentrations
achieved with a single oral dose of 300000 IU vitamin D3. METHODS: Over a course of 4
months, we identified 33 elderly with severe vitamin D deficiency (25 (OH) D< 25 nmol/l) on
admission to acute care. Patients were admitted for musculoskeletal pain, bone disease, or …
OBJECTIVES
Recent large trials indicate that adherence associated with a daily regimen of vitamin D is low and limits anti-fracture efficacy with vitamin D supplementation. The aim of this report is to describe changes of 25-hydroxyvitamin D (25(OH)D) serum concentrations achieved with a single oral dose of 300000 IU vitamin D3.
METHODS
Over a course of 4 months, we identified 33 elderly with severe vitamin D deficiency (25(OH)D<25 nmol/l) on admission to acute care. Patients were admitted for musculoskeletal pain, bone disease, or gait abnormalities. The mean age was 80.5 years (SD±6.1). All patients were treated with a single oral dose of 300000 IU D3 in combination with 500–1000 mg calcium supplements per day depending on their dietary calcium intake.
RESULTS
Baseline mean 25(OH)D serum concentrations were 15 nmol/l (SD±5.5). Mean 25(OH)D serum concentrations increased to 81.4 nmol/l (SD±29.7) at 3 months (29 patients) and were still 69.0 nmol/l (SD±17.9) at 6 months (26 patients). Mean serum calcium levels were 2.24 mmol/l (SD±0.11) at baseline, 2.28 mmol/l (SD±0.18) at 3 months, and 2.28 mmol/l (SD±0.13) at 6 months. Two patients with mild hypercalcemia (2.69 mmol/l) at 3 months had normal values at 6 months.
CONCLUSION
Based on our observations, a single oral dose of 300000 IU vitamin D3 raises mean 25(OH)D serum concentrations to the target mean of above 75 nmol/l at 3 months and a mean level of 69 nmol/l at 6 months. As calcium absorption is enhanced with higher 25(OH)D serum concentrations, calcium supplementation may need downward adjustment with this regimen to avoid mild hypercalcemia.
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