Unique Lipid A Modifications in Pseudomonas aeruginosa Isolated from the Airways of Patients with Cystic Fibrosis
RK Ernst, SM Moskowitz, JC Emerson… - The Journal of …, 2007 - academic.oup.com
The Journal of infectious diseases, 2007•academic.oup.com
Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of
aminoarabinose [positively charged amino sugar residue], and retention of 3-
hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa
isolates from patientswith cystic fibrosis (CF; n= 86), from the environment (n= 13), and from
patients with other conditions (n= 14). Among P. aeruginosa CF isolates, 100% had lipid A
with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None …
aminoarabinose [positively charged amino sugar residue], and retention of 3-
hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa
isolates from patientswith cystic fibrosis (CF; n= 86), from the environment (n= 13), and from
patients with other conditions (n= 14). Among P. aeruginosa CF isolates, 100% had lipid A
with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None …
Abstract
Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patientswith cystic fibrosis (CF; n = 86), from the environment (n = 13), and from patients with other conditions (n = 14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.
Oxford University Press