The immune system must effectively regulate the balance between beneficial and
detrimental inflammation. This process is achieved in part through cell surface receptors that
rapidly integrate activating and inhibitory signals. The inhibitory members of the leukocyte Ig‐
like receptor (LILR) family, termed LILRBs, are broadly distributed among cell populations in
the immune system and potently counterregulate cell activation induced by stimuli of innate
and adaptive immune responses. Studies in mice and humans indicate that LILRBs …